Thompson G A, Kilpatrick I C
Department of Cell Physiology and Pharmacology, University of Leicester, UK.
Pharmacol Ther. 1996;72(1):25-36. doi: 10.1016/s0163-7258(96)00097-6.
While L-glutamate (L-Glu) is considered to be the predominant excitatory amino acid transmitter in the mammalian CNS, other amino acids have come under scrutiny as possible rivals for such a role. These include four sulphur-containing analogues of L-Glu and L-aspartate known as the SAAs. The L-Glu analogues are L-homocysteic acid and L-homocysteine sulphinic acid, while the L-aspartate analogues are L-cysteic acid and L-cysteine sulphinic acid. They are mixed agonists of excitatory amino acid receptors on a variety of neurones and are reported to be present in and released from mammalian CNS tissue. This review serves to summarize the current state of research into the possibility that one or more of these compounds is indeed a transmitter within the mammalian CNS.
虽然L-谷氨酸（L-Glu）被认为是哺乳动物中枢神经系统中主要的兴奋性氨基酸递质，但其他氨基酸作为这一角色的潜在竞争者也受到了审视。这些氨基酸包括L-谷氨酸和L-天冬氨酸的四种含硫类似物，即硫代氨基酸（SAAs）。L-谷氨酸的类似物是L-高半胱氨酸和L-高半胱氨酸亚磺酸，而L-天冬氨酸的类似物是L-磺基丙氨酸和L-半胱氨酸亚磺酸。它们是多种神经元上兴奋性氨基酸受体的混合激动剂，据报道存在于哺乳动物中枢神经系统组织中并从中释放。这篇综述旨在总结目前关于这些化合物中的一种或多种是否确实是哺乳动物中枢神经系统内递质的研究现状。
