Chou W H, Hall K J, Wilson D B, Wideman C L, Townson S M, Chadwell L V, Britt S G
Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245.
Neuron. 1996 Dec;17(6):1101-15. doi: 10.1016/s0896-6273(00)80243-3.
The function of the compound eye is dependent upon a developmental program that specifies different cell fates and directs the expression of spectrally distinct opsins in different photoreceptor cells. Rh5 is a novel Drosophila opsin gene that encodes a biologically active visual pigment that is expressed in a subset of R8 photoreceptor cells. Rh5 expression in the R8 cell of an individual ommatidium is strictly coordinated with the expression of Rh3, in the overlying R7 cell. In sevenless mutant files, which lack R7 photoreceptor cells, the expression of the Rh5 protein in R8 cells is disrupted, providing evidence for a specific developmental signal between the R7 and R8 cells that is responsible for the paired expression of opsin genes.
复眼的功能依赖于一个发育程序，该程序指定不同的细胞命运，并指导在不同光感受器细胞中表达光谱不同的视蛋白。Rh5是一种新的果蝇视蛋白基因，它编码一种具有生物活性的视觉色素，在一部分R8光感受器细胞中表达。在单个小眼的R8细胞中，Rh5的表达与上方R7细胞中Rh3的表达严格协调。在缺乏R7光感受器细胞的无七突变果蝇中，R8细胞中Rh5蛋白的表达受到破坏，这为R7和R8细胞之间负责视蛋白基因配对表达的特定发育信号提供了证据。
