Sung H W, Hsu C S, Lee Y S
Department of Chemical Engineering, National Central University, Chung-Li, Taiwan, Republic of China.
Biomaterials. 1996 Dec;17(24):2357-65. doi: 10.1016/s0142-9612(96)00081-6.
This study aimed to investigate the physical properties of a porcine internal thoracic artery fixed with an epoxy compound. Fresh and glutaraldehyde-fixed porcine arteries were used as controls. Both the epoxy-fixed and glutaraldehyde-fixed porcine arteries showed significant increases in fixation index and denaturation temperature as compared to the fresh one. Additionally, the resistance of porcine arteries against bacterial collagenase in vitro degradation increased significantly after cross-linking with the epoxy compound of glutaraldehyde. The reduction of the tensile strength of the epoxy-fixed artery after bacterial collagenase degradation was more severe than in its glutaraldehyde-fixed counterpart. Generally, with increasing pH, temperature or fixative concentration, the fixation indices and denaturation temperatures of the epoxy-fixed porcine arteries increased. The results obtained in this study may be used to optimize the fixation process for developing a small-diameter biological vascular graft fixed by an epoxy compound.
本研究旨在调查用环氧化合物固定的猪胸廓内动脉的物理特性。新鲜的和用戊二醛固定的猪动脉用作对照。与新鲜猪动脉相比，用环氧化合物固定和用戊二醛固定的猪动脉在固定指数和变性温度方面均显著增加。此外，猪动脉与戊二醛的环氧化合物交联后，其体外抗细菌胶原酶降解的能力显著增强。细菌胶原酶降解后，环氧化合物固定动脉的拉伸强度降低比戊二醛固定的动脉更严重。一般来说，随着pH值、温度或固定剂浓度的增加，环氧化合物固定的猪动脉的固定指数和变性温度升高。本研究获得的结果可用于优化固定过程，以开发用环氧化合物固定的小直径生物血管移植物。
