Allen E A, Ali S Z, Erozan Y S
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287-6940, USA.
Diagn Cytopathol. 1996 Nov;15(4):349-51. doi: 10.1002/(SICI)1097-0339(199611)15:4<349::AID-DC20>3.0.CO;2-N.
Tumoral calcium pyrophosphate dihydrate deposition disease (CPPD) is a rare non-neoplastic entity which mimics primary or metastatic soft-tissue or skeletal malignancy. Fewer than a dozen cases have been reported in the literature with only histologic descriptions. We present cytologic findings of a unique case of CPPD in a 73-year-old black female with a history of end-stage renal disease. A fine-needle aspiration (FNA) was done on a 4 x 4-cm neck mass which was clinically thought to be malignant. Cytopathologic examination showed numerous macrophages with markedly distended cytoplasm and containing multiple yellowish-orange, short rhomboid crystals. These were strongly birefringent on polarized microscopy, consistent with CPPD crystals.
肿瘤性二水焦磷酸钙沉积病（CPPD）是一种罕见的非肿瘤性疾病，可模仿原发性或转移性软组织或骨骼恶性肿瘤。文献报道的病例不足12例，且仅有组织学描述。我们报告了一例73岁黑人女性CPPD独特病例的细胞学发现，该患者有终末期肾病病史。对一个临床认为是恶性的4×4cm颈部肿块进行了细针穿刺抽吸（FNA）。细胞病理学检查显示大量巨噬细胞，其细胞质明显扩张，含有多个黄橙色短菱形晶体。这些晶体在偏振显微镜下呈强双折射，与CPPD晶体一致。
