De Leon M J, George A E, Golomb J, Tarshish C, Convit A, Kluger A, De Santi S, McRae T, Ferris S H, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller D C, Wisniewski H M
Department of Psychiatry, New York University School of Medicine, NY 10016, USA.
Neurobiol Aging. 1997 Jan-Feb;18(1):1-11. doi: 10.1016/s0197-4580(96)00213-8.
We used CT and MR to examine the frequency of occurrence of hippocampal formation atrophy (HA) in a research clinic population of 130 normal elderly, 72 nondemented patients with very mild memory and cognitive impairments (MCI), 73 mild Alzheimer's disease (AD) patients, and 130 patients with moderate to severe AD. HA was found in 29% of the normal elderly group and its frequency of occurrence was strongly related to increasing age. For normal elderly 60-75 years of age, 15% had HA: the proportion rose to 48% in subjects 76-90 years of age. Among the three groups of impaired patients, the frequencies of HA ranged from 78% in the MCI patients to 96% in the advanced AD group. Unlike the normal elderly group, the percentages were not related to age. In both the normal elderly group and MCI group disproportionately more males than females had HA. After controlling for learning and the effects of generalized brain changes as reflected in ventricular size, only in the normal group was HA associated with reduced delayed verbal recall performance. Follow-up examinations for 15 individuals with baseline HA. 4 who at entry were MCI and 11 probable AD, yielded clinical and neuropathologic diagnoses of AD in all cases. The results of the present study indicate that hippocampal formation atrophy is associated with memory and cognitive impairments. Further longitudinal and neuropathologic work is required to validate the relationship between hippocampal formation atrophy and AD.
我们使用CT和MR检查了130名正常老年人、72名患有非常轻微记忆和认知障碍（MCI）的非痴呆患者、73名轻度阿尔茨海默病（AD）患者以及130名中度至重度AD患者的研究临床人群中海马结构萎缩（HA）的发生率。在正常老年组中，29%的人发现有HA，其发生率与年龄增长密切相关。对于60 - 75岁的正常老年人，15%有HA；在76 - 90岁的受试者中，这一比例上升至48%。在三组受损患者中，HA的发生率从MCI患者的78%到晚期AD组的96%不等。与正常老年组不同，这些百分比与年龄无关。在正常老年组和MCI组中，患有HA的男性比例均高于女性。在控制了学习以及脑室大小所反映的全脑变化的影响后，仅在正常组中，HA与延迟言语回忆表现降低相关。对15名基线时有HA的个体进行了随访检查。其中4名入组时为MCI，11名可能为AD，所有病例均得出了AD的临床和神经病理学诊断。本研究结果表明，海马结构萎缩与记忆和认知障碍有关。需要进一步开展纵向和神经病理学研究来验证海马结构萎缩与AD之间的关系。
