土曲霉环二醇的分子结构：来自土曲霉的抗真菌代谢产物土曲霉环酸A的衍生物。

Molecular structure of terrecyclodiol: a derivative of the antifungal metabolite terrecyclic acid A from Aspergillus terreus.

作者信息

Almassi F, Ghisalberti E L, Skelton B W, White A H

机构信息

Department of Chemistry, University of Western Australia, Nedlands.

出版信息

J Nat Prod. 1996 Jan;59(1):59-61. doi: 10.1021/np960008f.

DOI:10.1021/np960008f

PMID:8984154

Abstract

A strain of Aspergillus terreus, which was isolated from organic mulch and inhibited the growth of the plant pathogen Phytophthora cinnamomi, produces an antifungal metabolite when grown in liquid culture. This metabolite was isolated by bioassay-guided fractionation and identified as terrecyclic acid A (1). X-ray diffraction studies and spectroscopic details of the derived terrecyclodiol (2) are described.

摘要

从有机覆盖物中分离出的一株土曲霉，它能抑制植物病原菌樟疫霉的生长，该菌株在液体培养时会产生一种抗真菌代谢产物。通过生物测定引导的分级分离法分离出这种代谢产物，并鉴定为土曲霉环酸A（1）。文中描述了衍生的土曲霉环二醇（2）的X射线衍射研究和光谱细节。