Carluccio F, Amendola S
I Clinica Otorinolaringoiatrica, Policlinico Umberto, Università La Sapienza di Roma.
Acta Otorhinolaryngol Ital. 1996 Feb;16(1):57-61.
Oncocytic tumors rarely occur in major salivary glands and generally account for less than 1% of all salivary tumors. Oncocytomas are infrequent tumors that most commonly arise in the salivary, thyroid, parathyroid and pituitary glands, kidneys and pancreas. They are rarely malignant. Oncocytic differentiation may also occur focally in a benign or a malignant epithelial tumor, such as a thyroid adenoma, papillary cystadenoma lymphomatosum and mixed tumors of salivary glands, malignant carcinoids of the bronchus, adrenal cortical carcinoma, and renal cell carcinoma. The term oncocytoma refers to a single neoplasm contrast to nodular oncocytic hyperplasia, which refers to two or more distinct tumor nodules, and to oncocytic mucoepidermoid carcinomas, where there is evidence of infiltrative growth and malignant of clinical behavior. We here report surgical treatment and light and electron microscopical findings obtained in the case of an oncocytoma of the parapharyngeal prestyloid space in a 62-year-old man who was admitted to our Department because of a slowly enlarging, painless mass in the pharyngeal extension of the right parotid gland. The mass has distorted the isthmus of the fauces, compressing the contra lateral pharyngeal-palatal plica. A total right parotidectomy which spared the branches of the facial nerve was performed. During the operative procedure, tissue was removed for frozen-section examination. The patient had an uneventful post-operative course. For all that has previously been written about oncocytic tumors, relatively very little is known of their etiology. In the past a correlation was made between the etiology and the history of direct or indirect radiation exposure. As oncocytic metaplasia and oncocytomas are often seen most in older individuals, the oncocyte was previously regarded as a "functional exhaustion" of a normal cell. As far as we concerned, the preferred method of surgically exposing the parapharyngeal-prestyloid space is that of removing the parotid gland through a cervical approach. Because of the proximity of certain anatomical structures, the transoral approach is not the most suitable.
嗜酸细胞瘤很少发生于大唾液腺,一般占所有唾液腺肿瘤的比例不到1%。嗜酸细胞瘤是一种罕见的肿瘤,最常见于唾液腺、甲状腺、甲状旁腺和垂体、肾脏及胰腺。它们很少为恶性。嗜酸细胞分化也可能局灶性地出现在良性或恶性上皮性肿瘤中,如甲状腺腺瘤、乳头状囊腺瘤淋巴瘤和唾液腺混合瘤、支气管恶性类癌、肾上腺皮质癌和肾细胞癌。嗜酸细胞瘤一词指单个肿瘤,与结节性嗜酸细胞增生(指两个或更多不同的肿瘤结节)以及嗜酸细胞黏液表皮样癌形成对比,后者有浸润性生长和临床行为恶性的证据。我们在此报告一例62岁男性咽旁茎突前间隙嗜酸细胞瘤的手术治疗及光镜和电镜检查结果,该患者因右侧腮腺咽侧缓慢增大的无痛性肿块入院。肿块使咽峡变形,压迫对侧咽腭皱襞。实施了保留面神经分支的右侧腮腺全切除术。手术过程中,取组织进行冰冻切片检查。患者术后恢复顺利。尽管此前已有关于嗜酸细胞瘤的诸多报道,但对其病因了解相对较少。过去曾将病因与直接或间接辐射暴露史联系起来。由于嗜酸细胞化生和嗜酸细胞瘤常见于老年人,嗜酸细胞以前被认为是正常细胞的“功能耗竭”。就我们而言,手术暴露咽旁茎突前间隙的首选方法是通过颈部入路切除腮腺。由于某些解剖结构位置相邻,经口入路并非最合适的方法。