Laurence A S, Vanner G K, Collins W, Hopkins P M
Department of Anaesthetics, Royal Preston Hospital.
Anaesthesia. 1996 Oct;51(10):958-61. doi: 10.1111/j.1365-2044.1996.tb14965.x.
A 13-year-old boy presenting for correction of bat ears was anaesthetised with thiopentone and suxamethonium, the administration of which was followed by jaw spasm, poor peripheral perfusion (without cyanosis) and marked tachycardia. The procedure was abandoned, dantrolene and Ringer lactate IL were given intravenously and the patient regained consciousness 1 h later. Levels of serum myoglobin, urinary myoglobin and creatine kinase were followed until they returned to normal. Despite a peak serum myoglobin of 58.000 micrograms.l-1 and peak urinary level of 446,000 micrograms.l-1, no renal impairment occurred. Subsequent testing for susceptibility to malignant hyperthermia proved positive for the patient and four other members of the family.
一名13岁因招风耳前来矫正的男孩，用硫喷妥钠和琥珀酰胆碱麻醉，用药后出现牙关痉挛、外周灌注不良（无发绀）和明显心动过速。手术取消，静脉注射丹曲林和1升乳酸林格液，患者1小时后恢复意识。监测血清肌红蛋白、尿肌红蛋白和肌酸激酶水平直至恢复正常。尽管血清肌红蛋白峰值达58000微克/升，尿肌红蛋白峰值达446000微克/升，但未发生肾功能损害。随后对该患者及其家族中其他四名成员进行恶性高热易感性检测，结果呈阳性。
