Magee J C, Johnston D
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Science. 1997 Jan 10;275(5297):209-13. doi: 10.1126/science.275.5297.209.
The role of back-propagating dendritic action potentials in the induction of long-term potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings and simultaneous calcium imaging. Pairing of subthreshold excitatory postsynaptic potentials (EPSPs) with back-propagating action potentials resulted in an amplification of dendritic action potentials and evoked calcium influx near the site of synaptic input. This pairing also induced a robust LTP, which was reduced when EPSPs were paired with non-back-propagating action potentials or when stimuli were unpaired. Action potentials thus provide a synaptically controlled, associative signal to the dendrites for Hebbian modifications of synaptic strength.
通过树突膜片钳记录和同步钙成像技术，研究了反向传播的树突动作电位在CA1神经元长时程增强（LTP）诱导中的作用。阈下兴奋性突触后电位（EPSP）与反向传播动作电位配对，导致树突动作电位放大，并在突触输入部位附近诱发钙内流。这种配对还诱导了强烈的LTP，当EPSP与非反向传播动作电位配对或刺激未配对时，LTP会减弱。因此，动作电位为树突提供了一个由突触控制的关联信号，用于对突触强度进行赫布式修饰。
