Mansfield K G, Lackner A A
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9012, USA.
J Infect Dis. 1997 Jan;175(1):184-7. doi: 10.1093/infdis/175.1.184.
During the terminal stages of AIDS, Mycobacterium avium complex (MAC) infection is the most common disseminated bacterial infection in rhesus macaques (Macaca mulatta) experimentally inoculated with the simian immunodeficiency virus (SIV). The source of mycobacterial infection in 15 SIV-inoculated rhesus macaques housed in a biolevel 3 containment facility was investigated using a sensitive polymerase chain reaction typing technique. Six animal isolates had banding profiles identical to that of 1 environmental isolate obtained from the facility's water distribution system. An additional 6 isolates had banding profiles differing by the addition or loss of one or two bands from this and 1 other water isolate. These findings indicate that potable water may serve as a significant source of mycobacterial infection in SIV-inoculated macaques and suggest that strategies to prevent exposure to mycobacteria within potable water should be investigated as a method to prevent mycobacteriosis in human immunodeficiency virus-infected persons.
在艾滋病终末期，鸟分枝杆菌复合体（MAC）感染是实验性接种猿猴免疫缺陷病毒（SIV）的恒河猴（猕猴）中最常见的播散性细菌感染。使用灵敏的聚合酶链反应分型技术，对饲养在生物安全3级隔离设施中的15只接种SIV的恒河猴的分枝杆菌感染源进行了调查。6株动物分离株的条带图谱与从该设施供水系统获得的1株环境分离株相同。另外6株分离株的条带图谱与这株及另一株水分离株相比，有一两条带的增减。这些发现表明，饮用水可能是接种SIV猕猴分枝杆菌感染的重要来源，并提示应研究预防接触饮用水中分枝杆菌的策略，作为预防人类免疫缺陷病毒感染者发生分枝杆菌病的一种方法。
