种间氨肽酶-N嵌合体揭示了犬冠状病毒、猫传染性腹膜炎病毒和传染性胃肠炎病毒对物种特异性受体的识别。
Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus.
作者信息
Benbacer L, Kut E, Besnardeau L, Laude H, Delmas B
机构信息
Unité de Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
出版信息
J Virol. 1997 Jan;71(1):734-7. doi: 10.1128/JVI.71.1.734-737.1997.
Abstract
We report that cells refractory to canine coronavirus (CCV) and feline infectious peritonitis virus (FIPV) became susceptible when transfected with a chimeric aminopeptidase-N (APN) cDNA containing a canine domain between residues 643 and 841. This finding shows that APN recognition by these viruses is species related and associated with this C-terminal domain. The human/canine APN chimera was also able to confer susceptibility to the porcine transmissible gastroenteritis virus (TGEV), whereas its human/porcine homolog failed to confer susceptibility to CCV and FIPV. A good correlation was observed between the capacity of CCV, FIPV, and TGEV to recognize the different interspecies APN chimeras and their ability to infect cells derived from the relevant species. As an exception, TGEV was found to use a human/bovine APN chimera as a receptor although itself unable to replicate in bovine cells.
摘要
我们报告称，对犬冠状病毒（CCV）和猫传染性腹膜炎病毒（FIPV）具有抗性的细胞，在转染了一个嵌合氨肽酶-N（APN）cDNA后变得易感，该cDNA在第643至841位残基之间包含一个犬类结构域。这一发现表明，这些病毒对APN的识别与物种相关，且与该C末端结构域有关。人/犬APN嵌合体也能够使细胞对猪传染性胃肠炎病毒（TGEV）易感，而其人/猪同源物则不能使细胞对CCV和FIPV易感。观察到CCV、FIPV和TGEV识别不同种间APN嵌合体的能力与其感染相关物种来源细胞的能力之间存在良好的相关性。作为一个例外，发现TGEV使用人/牛APN嵌合体作为受体，尽管它本身无法在牛细胞中复制。
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