Tamburini M, Malatesta M, Zancanaro C, Martin T E, Fu X D, Vogel P, Fakan S
Centre of Electron Microscopy, University of Lausanne, Switzerland.
Histochem Cell Biol. 1996 Dec;106(6):581-6. doi: 10.1007/BF02473273.
Dense granular bodies (DGB) are particular structural constituents observed in cell nuclei of different tissues-liver, pancreas, brown adipose tissue, adrenal cortex-of hibernating dormice. They appear as strongly electron-dense clusters of closely packed granules, with thin fibrils spreading out at their periphery. DGB always occur in the nucleoplasm, sometimes making contact with other nuclear structural constituents typical of the hibernating state, such as coiled bodies, amorphous bodies and nucleoplasmic fibrils. DGB are present only during deep hibernation and rapidly disappear upon arousal from hibernation. Cytochemical and immunocytochemical analyses showed that DGB contain ribonucleoproteins and several nucleoplasmic RNA processing factors, suggesting that DGB can represent accumulation sites of splicing factors which are provided to splicing sites when normal metabolic activity is rapidly restored during arousal.
致密颗粒体（DGB）是在冬眠睡鼠的不同组织（肝脏、胰腺、棕色脂肪组织、肾上腺皮质）的细胞核中观察到的特殊结构成分。它们表现为紧密堆积的颗粒形成的强电子致密簇，在其周边有细纤维伸展。DGB总是出现在核质中，有时与冬眠状态典型的其他核结构成分接触，如卷曲体、无定形体和核质纤维。DGB仅在深度冬眠期间存在，并在从冬眠中苏醒时迅速消失。细胞化学和免疫细胞化学分析表明，DGB含有核糖核蛋白和几种核质RNA加工因子，这表明DGB可能代表剪接因子的积累位点，在苏醒期间正常代谢活动迅速恢复时，这些剪接因子会被提供到剪接位点。
