Wu C W, Tsay S H, Hsieh M C, Lo S S, Lui W Y, P'eng F K
Department of Surgery, Veterans General Hospital-Taipei, Taiwan, Republic of China.
J Gastroenterol Hepatol. 1996 Nov;11(11):1083-8. doi: 10.1111/j.1440-1746.1996.tb00041.x.
The present study sought to evaluate the clinicopathological features of our gastric cancer patients in terms of a modified Lauren's histological classification and compared the results with those from studies from Japan and Western countries. A total of 536 consecutive patients with gastric cancer were treated surgically between December 1987 and December 1993. A clinicopathological analysis was only performed for intestinal types (IT) and diffuse types (DT) of gastric cancer because patients falling into the 'other' category were too small to produce meaningful data. Of 536 cases of gastric cancer, 268 (50%) were IT, 231 (43.1%) were DT and 37 (6.9%) were of the other type. The overall IT:DT ratio was 1.2. Gastric cancer patients with IT (in contrast to DT) were characterized by older age, male dominance, smaller tumours, the tumour often being located in the lower and upper third of the stomach and less peritoneal metastasis. In both sexes, the peak incidence of gastric cancer patients was in the age group 65-74 years. Men had higher proportions of IT carcinoma than women. The IT:DT ratio for men and women was 1.4 and 0.4, respectively. Although the increased ratio of IT:DT paralleled the advance of age in both sexes, the transitional age (the age at which the IT:DT ratio exceeds 1.0) in male patients (age group 51-64 years) was earlier than for female patients (age group 65-74 years). Patients with IT gastric cancer had a significantly better survival rate than those with DT. However, the type of carcinoma (IT or DT) was not an independent predictor of survival. These data indicate that gastric cancer in Taiwan Chinese has different biological behaviour in terms of IT and DT. The clinicopathological features in IT and DT carcinoma are similar to studies from Japan and from Western countries.
本研究旨在根据改良的劳伦组织学分类法评估我国胃癌患者的临床病理特征，并将结果与日本和西方国家的研究结果进行比较。1987年12月至1993年12月期间，共有536例连续性胃癌患者接受了手术治疗。仅对胃癌的肠型（IT）和弥漫型（DT）进行了临床病理分析，因为归入“其他”类别的患者数量太少，无法得出有意义的数据。在536例胃癌病例中，268例（50%）为IT型，231例（43.1%）为DT型，37例（6.9%）为其他类型。IT型与DT型的总体比例为1.2。IT型胃癌患者（与DT型相比）的特点是年龄较大、男性居多、肿瘤较小、肿瘤常位于胃的下三分之一和上三分之一，且腹膜转移较少。在男女两性中，胃癌患者的发病高峰年龄均在65 - 74岁年龄组。男性IT癌的比例高于女性。男性和女性的IT型与DT型比例分别为1.4和0.4。尽管IT型与DT型比例的增加在两性中均与年龄的增长平行，但男性患者（51 - 64岁年龄组）的转变年龄（IT型与DT型比例超过1.0的年龄）早于女性患者（65 - 74岁年龄组）。IT型胃癌患者的生存率明显高于DT型患者。然而，癌的类型（IT型或DT型）并非生存的独立预测因素。这些数据表明，台湾华人的胃癌在IT型和DT型方面具有不同的生物学行为。IT型和DT型癌的临床病理特征与日本和西方国家的研究相似。
