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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gluckman B J, Neel E J, Netoff T I, Ditto W L, Spano M L, Schiff S J

Naval Surface Warfare Center, White Oak Laboratory, Silver Spring, Maryland 20903, USA.

J Neurophysiol. 1996 Dec;76(6):4202-5. doi: 10.1152/jn.1996.76.6.4202.

The effects of relatively small external DC electric fields on synchronous activity in CA1 and CA3 from transverse and longitudinal type hippocampal slices were studied. 2. To record neuronal activity during significant field changes, differential DC amplification was employed with a reference electrode aligned along an isopotential with the recording electrode. 3. Suppression of epileptiform activity was observed in 31 of 33 slices independent of region studied and type of slice but was highly dependent on field orientation with respect to the apical dendritic-somatic axis. 4. Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5-10 mV/mm. Suppression was seen with the field oriented (positive to negative potential) from the soma to the apical dentrites. 5. In vivo application of these results may be feasible.

研究了相对较小的外部直流电场对横向和纵向海马切片中CA1和CA3同步活动的影响。2. 为了在显著的场变化期间记录神经元活动，采用了差分直流放大，参考电极与记录电极沿等电位线对齐。3. 在33个切片中的31个中观察到癫痫样活动的抑制，与研究的区域和切片类型无关，但高度依赖于电场相对于顶端树突-胞体轴的方向。4. 在这些实验中，在电场强度≤5-10 mV/mm时很容易观察到神经元活动的调制。当电场从胞体指向顶端树突（正电位到负电位）时，会出现抑制。5. 将这些结果应用于体内可能是可行的。

Gluckman B J, Neel E J, Netoff T I, Ditto W L, Spano M L, Schiff S J

Naval Surface Warfare Center, White Oak Laboratory, Silver Spring, Maryland 20903, USA.

J Neurophysiol. 1996 Dec;76(6):4202-5. doi: 10.1152/jn.1996.76.6.4202.

The effects of relatively small external DC electric fields on synchronous activity in CA1 and CA3 from transverse and longitudinal type hippocampal slices were studied. 2. To record neuronal activity during significant field changes, differential DC amplification was employed with a reference electrode aligned along an isopotential with the recording electrode. 3. Suppression of epileptiform activity was observed in 31 of 33 slices independent of region studied and type of slice but was highly dependent on field orientation with respect to the apical dendritic-somatic axis. 4. Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5-10 mV/mm. Suppression was seen with the field oriented (positive to negative potential) from the soma to the apical dentrites. 5. In vivo application of these results may be feasible.

研究了相对较小的外部直流电场对横向和纵向海马切片中CA1和CA3同步活动的影响。2. 为了在显著的场变化期间记录神经元活动，采用了差分直流放大，参考电极与记录电极沿等电位线对齐。3. 在33个切片中的31个中观察到癫痫样活动的抑制，与研究的区域和切片类型无关，但高度依赖于电场相对于顶端树突-胞体轴的方向。4. 在这些实验中，在电场强度≤5-10 mV/mm时很容易观察到神经元活动的调制。当电场从胞体指向顶端树突（正电位到负电位）时，会出现抑制。5. 将这些结果应用于体内可能是可行的。