Galletly C
Department of Psychiatry, Queen Elizabeth Hospital, Adelaide, South Australia.
Ann Clin Psychiatry. 1996 Dec;8(4):189-92. doi: 10.3109/10401239609147758.
Four cases of patients who described an unpleasant subjective experience of weakness and reduced muscle tone during treatment with clozapine are presented. An exacerbation of muscular dystrophy during clozapine treatment is also described. It is hypothesized that these adverse effects are related to the muscle relaxant properties of clozapine. The differential diagnosis of sedation, fatigue, asthenia, and reduced muscle tone is discussed.
本文介绍了4例患者，这些患者在使用氯氮平治疗期间描述了虚弱和肌张力降低的不愉快主观体验。还描述了氯氮平治疗期间肌肉萎缩的加重情况。据推测，这些不良反应与氯氮平的肌肉松弛特性有关。文中讨论了镇静、疲劳、乏力和肌张力降低的鉴别诊断。
