Wang Ying-Chou, Hsiao Sigmund
Department of Psychology,Ching Kuo Institute of Management and Health, National Chung Cheng University, Chia Yi 621, Taiwan.
Behav Neurosci. 2003 Oct;117(5):961-9. doi: 10.1037/0735-7044.117.5.961.
Rats, pretreated with amphetamine (AMPH, 1 mg/kg) or saline for 2 weeks, were challenged with AMPH (0.5 mg/kg) or saline following 1 week of abstinence, and locomotion was measured. In Experiments 1 and 2, the pretreatment occurred in various contexts (home cage, novel box, test box). Sensitization was observed only when pretreatment context and test context were the same; a context switch abolished sensitization. When rats anesthetized with chloral hydrate were pretreated with AMPH, sensitization was completely dependent on the pretreatment, but independent of context. This "zero context" condition isolated the basal level of excitation attributable to unconditioned neural change to determine the role of contextual input to be a modulator that enhances or inhibits sensitization.
大鼠先用苯丙胺（AMPH，1毫克/千克）或生理盐水预处理2周，在禁欲1周后再用AMPH（0.5毫克/千克）或生理盐水进行激发，然后测量其运动能力。在实验1和实验2中，预处理在不同环境（饲养笼、新盒子、测试盒）中进行。仅当预处理环境和测试环境相同时才观察到敏化作用；环境转换会消除敏化作用。当用氯水合醛麻醉的大鼠用AMPH预处理时，敏化作用完全取决于预处理，但与环境无关。这种“零环境”条件分离出了由非条件神经变化引起的基础兴奋水平，以确定环境输入作为增强或抑制敏化作用的调节因子的作用。
