Ward I L, Ward O B, French J A, Hendricks S E, Mehan D, Winn R J
Department of Psychology, Villanova University, Pennsylvania 19085.
Behav Neurosci. 1996 Dec;110(6):1469-77. doi: 10.1037//0735-7044.110.6.1469.
Restraint stress reduced blood alcohol levels in pregnant rats given a liquid alcohol diet. The male offspring prenatally exposed to both stress and alcohol failed to ejaculate spontaneously, although they copulated normally following exogenous testosterone (T) administration. Males prenatally exposed only to alcohol or only to stress showed no behavioral deficits. Adult serum T and luteinizing hormone levels were normal in both of the fetal alcohol exposed male groups. It appears that the androgen threshold for ejaculatory behavior is elevated in males prenatally exposed to alcohol plus stress and cannot be realized with normal testosterone titers, but it can be attained with exogenous hormone administration. Presumably the alcohol and stress combination interfered with ontogenetic patterns of T needed to fully masculinize the fetal nervous system.
在给予液体酒精饮食的怀孕大鼠中，束缚应激降低了血液酒精水平。产前同时暴露于应激和酒精的雄性后代不能自发射精，尽管在给予外源性睾酮（T）后它们能正常交配。仅产前暴露于酒精或仅暴露于应激的雄性没有表现出行为缺陷。两个胎儿酒精暴露雄性组的成年血清T和促黄体生成素水平均正常。似乎产前暴露于酒精加应激的雄性射精行为的雄激素阈值升高，正常的睾酮水平无法实现，但外源性激素给药可以达到该阈值。推测酒精和应激的组合干扰了使胎儿神经系统完全男性化所需的T的个体发育模式。
