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大鼠暴露于60赫兹磁场后出现空间学习缺陷。

Spatial learning deficit in the rat after exposure to a 60 Hz magnetic field.

作者信息

Lai H

机构信息

Bioelectromagnetics Research laboratory, University of Washington, Seattle 98195, USA.

出版信息

Bioelectromagnetics. 1996;17(6):494-6. doi: 10.1002/(SICI)1521-186X(1996)17:6<494::AID-BEM9>3.0.CO;2-Z.

DOI:10.1002/(SICI)1521-186X(1996)17:6<494::AID-BEM9>3.0.CO;2-Z
PMID:8986367
Abstract

Rats were trained in ten daily sessions to perform in a 12-arm radial maze, which is a behavioral test for spatial memory functions. Exposure to a 60 Hz magnetic field (45 min, 0.75 mT) immediately before each training session retarded learning significantly. Pretreatment with the cholinergic agonist physostigmine before magnetic field exposure reversed the field's effect on spatial learning. Data from this experiment indicate that magnetic field-induced spatial learning deficit is caused by the effect of the field on cholinergic systems.

摘要

大鼠每天接受十次训练,以便在十二臂放射状迷宫中完成任务,该迷宫是一种用于测试空间记忆功能的行为测试。在每次训练前立即暴露于60赫兹磁场(45分钟,0.75毫特斯拉)会显著延缓学习进程。在磁场暴露前用胆碱能激动剂毒扁豆碱进行预处理可逆转磁场对空间学习的影响。该实验数据表明,磁场诱导的空间学习缺陷是由磁场对胆碱能系统的作用所致。

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