Wenisch H J
Dept. of Surgery, Johann Wolfgang Goethe-University, Frankfurt arn Main, Germany.
Exp Clin Endocrinol Diabetes. 1996;104 Suppl 3:61-3. doi: 10.1055/s-0029-1211690.
A nude mouse xenotransplantation model was established for human thyroid carcinomas of different histological types. Best results of serial passages were obtained in anaplastic cancers. The models allowed investigations under in vivo conditions. Hormonal influences were tested, and imaging procedures were possible. In most aggressive anaplastic carcinoma cell lines, growth inhibition of cytostatic drugs, cytokines and nutritional effects were investigated.
建立了不同组织学类型人甲状腺癌的裸鼠异种移植模型。未分化癌的连续传代取得了最佳结果。这些模型可用于体内条件下的研究。测试了激素影响，并可行成像程序。在大多数侵袭性未分化癌细胞系中，研究了细胞毒性药物、细胞因子的生长抑制作用以及营养效应。
