Fields C
National Center for Genome Resources, Santa Fe, NM 87505, USA.
Trends Biotechnol. 1996 Aug;14(8):286-9. doi: 10.1016/0167-7799(96)10035-4.
Methods and technologies currently being developed promise an increase of between one and two orders of magnitude in the practical throughputs of DNA sequencing for gene discovery, expression analysis and variant analysis. Integrated laboratories will use all of these methods as components of a molecular strategy for the functional characterization of genes and their products. This review summarizes the types of data produced by these strategies, and the analysis and management challenges that they raise.
目前正在开发的方法和技术有望使用于基因发现、表达分析和变异分析的DNA测序实际通量提高1至2个数量级。综合实验室将把所有这些方法作为基因及其产物功能表征分子策略的组成部分。本综述总结了这些策略产生的数据类型，以及它们所带来的分析和管理挑战。
