Thévenet D, D'Ari R, Bouloc P
Institut Jacques Monod, CNRS, Université Paris 7, France.
J Biotechnol. 1996 Jun 27;47(2-3):89-97. doi: 10.1016/0168-1656(96)01384-3.
Microgravity affects certain physical properties of fluids, such as convection movement and surface tension. As a consequence, cells and living organisms may exhibit different behaviour in space, which may result from differences in the immediate environment of the cell or changes in the structure of the membrane in microgravity. Two experiments to examine the effects of microgravity on cell microenvironment and signal transduction through membranes were performed using a well-characterized system with different strains of the non-pathogenic Gram-negative bacterium Escherichia coli. Our results indicate that (i) microgravity appears to reduce the lag period of a non-motile culture of E. coli, and (ii) the ompC gene, regulated by the two-component system EnvZ-OmpR, is induced as well or better in microgravity than in ground controls.
微重力会影响流体的某些物理特性，比如对流运动和表面张力。因此，细胞和生物体在太空中可能会表现出不同的行为，这可能是由于细胞所处的直接环境差异或微重力下细胞膜结构的变化所致。利用一种具有不同非致病性革兰氏阴性大肠杆菌菌株的特征明确的系统，进行了两项实验，以研究微重力对细胞微环境和通过细胞膜的信号转导的影响。我们的结果表明：（i）微重力似乎会缩短大肠杆菌非运动型培养物的滞后期；（ii）由双组分系统EnvZ-OmpR调控的ompC基因，在微重力环境下的诱导情况与地面对照相当或更好。
