Kakuda T, Sakane I, Takihara T, Tsukamoto S, Kanegae T, Nagoya T
Central Research Institute, Itoen Ltd., Shizuoka, Japan.
Biosci Biotechnol Biochem. 1996 Sep;60(9):1450-4. doi: 10.1271/bbb.60.1450.
The effects of a green tea (Camellia sinensis) extract on ethanol metabolism in ICR male mice were studied. A crude green tea extract (GTE) and the tea components as (-)-epigallocatechin gallate (EGCg), (-)-epigallocatechin (EGC), and caffeine were administered before the tests. One hour later, the mice were orally given 2g/kg body weight (b.w.) of ethanol (20% ethanol w/v). The results show that the levels in the blood and liver of ethanol and acetaldehyde were lower, and that the levels of acetate and acetone were higher than in the controls orally given 500 mg/kg b.w. of GTE. After the administration of 75 mg/kg b.w. and 225 mg/kg b.w. of EGCg, the acetate and acetone concentrations in the blood and liver were lower than in the controls. The mice given caffeine at the same dose as that in GTE showed almost the same effects as the group treated with GTE. This suggests that EGCg and caffeine, the principal components of GTE, both had an effect on ethanol metabolism.
研究了绿茶（茶树）提取物对ICR雄性小鼠乙醇代谢的影响。在测试前给予粗绿茶提取物（GTE）以及茶成分如（-）-表没食子儿茶素没食子酸酯（EGCg）、（-）-表没食子儿茶素（EGC）和咖啡因。一小时后，给小鼠口服2g/kg体重（b.w.）的乙醇（20%乙醇w/v）。结果表明，与口服500mg/kg b.w. GTE的对照组相比，乙醇和乙醛在血液和肝脏中的水平较低，而乙酸盐和丙酮的水平较高。给予75mg/kg b.w.和225mg/kg b.w.的EGCg后，血液和肝脏中乙酸盐和丙酮的浓度低于对照组。给予与GTE中相同剂量咖啡因的小鼠表现出与GTE处理组几乎相同的效果。这表明GTE的主要成分EGCg和咖啡因均对乙醇代谢有影响。
