Söllner T H, Rothman J E
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Experientia. 1996 Dec 15;52(12):1021-5. doi: 10.1007/BF01952097.
A general machinery buds and fuses transport vesicles which connect intracellular compartments with each other and allow communication with the extracellular environment. Cytoplasmic coat proteins deform membranes to bud vesicles and interact directly or indirectly with cargo molecules. Compartment-specific SNAREs (SNAP receptors) on vesicles and target membranes dock vesicles and provide a scaffolding for the general fusion machinery to initiate lipid bilayer fusion.
一种通用的机制会出芽并融合运输小泡，这些小泡将细胞内的各个区室相互连接起来，并实现与细胞外环境的通讯。细胞质衣被蛋白使膜变形以形成小泡，并直接或间接地与货物分子相互作用。小泡和靶膜上特定区室的SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）使小泡对接，并为通用融合机制提供一个支架，以启动脂质双层融合。
