Wheeler P G, Melia W, Dubbins P, Jones B, Nunnerley H, Johnson P, Williams R
Br Med J. 1979 Jul 28;2(6184):242-4. doi: 10.1136/bmj.2.6184.242.
Three patients with primary hepatic tumours were treated by selective arterial embolisation with gelatin-foam fragments to induce necrosis. In the two with histologically proved hepatocellular carcinoma ultrasonography suggested that necrosis had been induced, as did the rapid initial falls in serum alpha-fetoprotein concentration by 95 and 81% of the original values respectively. Treatment was continued with a course of adriamycin, and both patients remained well and symptom free at 10 and 12 months. In the third patient, who had an expanding and highly vascular benign hepatic adenoma associated with use of a contraceptive pill, embolisation obliterated the tumour mass. Tumour embolisation should be regarded as only the first step in managing hepatocellular carcinoma and as a means of reducing appreciably the viable tumour mass before chemotherapy. It may be used as the primary and definitive treatment in patients with benign liver tumours.
三名原发性肝肿瘤患者接受了用明胶海绵碎片进行选择性动脉栓塞以诱导坏死的治疗。在两名经组织学证实为肝细胞癌的患者中，超声检查提示已诱导坏死，血清甲胎蛋白浓度最初也分别迅速下降了95%和81%。继续给予阿霉素疗程治疗，两名患者在10个月和12个月时均状况良好且无症状。第三名患者患有与使用避孕药有关的、不断增大且血管丰富的良性肝腺瘤，栓塞使肿瘤块消失。肿瘤栓塞应仅被视为肝细胞癌治疗的第一步，以及在化疗前显著减少存活肿瘤块的一种手段。它可作为良性肝肿瘤患者的主要和确定性治疗方法。
