Bonne O, Krausz Y, Gorfine M, Karger H, Gelfin Y, Shapira B, Chisin R, Lerer B
Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusolem 91120, Israel.
J Affect Disord. 1996 Dec 16;41(3):163-71. doi: 10.1016/s0165-0327(96)00058-4.
Functional imaging studies generally show decreased cerebral metabolism and perfusion in depressed patients relative to normal controls, although the location of the deficits varies. We used Tc99m HMPAO SPECT to compare cerebral blood flow in medication resistant, depressed patients and a normal control group. HMPAO uptake ratios (adjusted for age) were significantly lower in the depressed patients in the transaxial slices 4 cm and 6 cm above the orbitomeatal line (OML) on the left side. Examining individual regions of interest (corrected for age and multiple testing), we found significantly lower perfusion in the left superior temporal, right parietal and bilateral occipital regions in the patient group. These findings are in limited agreement with previous HMPAO SPECT studies. Methodological differences between studies, particularly variability in adjusting data for age, lead to a divergence in findings. Future research should seek to standardize protocols and data analysis in order to generate comparable results.
功能成像研究通常显示，与正常对照组相比，抑郁症患者的大脑代谢和灌注降低，尽管缺陷的位置有所不同。我们使用锝-99m六甲基丙烯胺肟单光子发射计算机断层扫描（Tc99m HMPAO SPECT）来比较药物难治性抑郁症患者和正常对照组的脑血流量。在左侧眶耳线（OML）上方4厘米和6厘米的横断面切片中，抑郁症患者的六甲基丙烯胺肟摄取率（根据年龄调整）显著较低。检查各个感兴趣区域（根据年龄和多次检验校正），我们发现患者组左侧颞上叶、右侧顶叶和双侧枕叶区域的灌注显著较低。这些发现与先前的六甲基丙烯胺肟单光子发射计算机断层扫描研究的一致性有限。研究之间的方法学差异，特别是在根据年龄调整数据方面的变异性，导致了研究结果的差异。未来的研究应寻求使方案和数据分析标准化，以便产生可比的结果。
