Mølbak K, Andersen M, Aaby P, Højlyng N, Jakobsen M, Sodemann M, da Silva A P
Epidemiology Research Unit, Danish Epidemiology Science Centre, Copenhagen, Denmark.
Am J Clin Nutr. 1997 Jan;65(1):149-52. doi: 10.1093/ajcn/65.1.149.
Cryptosporidium parvum causes persistent diarrhea in young children in developing countries. To determine the interaction between nutritional status and cryptosporidiosis, an open cohort of 1064 children younger than 3 y of age was followed for 1441 child-years by weekly diarrhea recall visits. A total of 5072 weight and 4264 height measurements was made. There were no tendencies of low weight (P = 0.38) or height (P = 0.16) in children who acquired cryptosporidiosis. Cryptosporidiosis in infancy was accompanied by an estimated weight loss of 392 g (95% CI: 247, 538 g) in boys and 294 g (95% CI: 109, 479 g) in girls, corresponding to 3.7% and 2.9% of mean weight, respectively, at 2 y of age. No significant catch-up growth covered for this loss in weight. A similar effect in linear growth was shown (P = 0.02). Although it has been suggested that the effect of infections on nutrition is usually transient because of catch-up growth, the present study suggests that cryptosporidiosis in infancy has a permanent effect on growth.
微小隐孢子虫可导致发展中国家幼儿持续性腹泻。为确定营养状况与隐孢子虫病之间的相互作用，对1064名3岁以下儿童组成的开放队列进行了为期1441人年的随访，通过每周回忆性腹泻访视来进行。共进行了5072次体重测量和4264次身高测量。感染隐孢子虫病的儿童没有低体重（P = 0.38）或身高偏低（P = 0.16）的倾向。婴儿期感染隐孢子虫病的男孩估计体重减轻392克（95%可信区间：247, 538克），女孩体重减轻294克（95%可信区间：109, 479克），分别相当于2岁时平均体重的3.7%和2.9%。体重减轻后没有明显的追赶生长。线性生长也有类似影响（P = 0.02）。尽管有人提出，由于追赶生长，感染对营养的影响通常是短暂的，但本研究表明，婴儿期隐孢子虫病对生长有永久性影响。
