Bessinger R, Beilke M, Kissinger P, Jarrott C, Tabak O F
HIV Outpatient Program, Louisiana State University Medical Center, New Orleans 70112, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jan 1;14(1):67-71. doi: 10.1097/00042560-199701010-00011.
The purpose of the study was to determine the seroprevalence of human T-lymphotropic virus types I and II (HTLV-I and HTLV-II) infections in an outpatient clinic population of human immunodeficiency virus (HIV)-1 infected persons as well as to identify the demographic and clinical characteristics and laboratory results associated with HTLV-I/II infections. During 1993-1995, 854 patients were tested for HTLV-I/II infection on entry into the clinic, of whom 25 were infected with HTLV-I and 35 with HTLV-II. Multivariate analysis revealed that patients with coinfections were more likely to be black, aged over 35 years, and have a history of injection drug use. HIV-1/HTLV-I coinfections were associated with higher median CD8 counts on entry (p < 0.05), and HIV-1/HTLV-II coinfections were associated with higher median percent CD4 counts (p < 0.05) compared with patients infected with HIV only. Coinfection was not associated with an increased diagnosis of AIDS. These findings indicate that HIV-1/HTLV-I/II coinfections are frequently diagnosed and are associated with unique immune phenotypes. Given the lack of information regarding the influence of dual infection on clinical status, differentiation of HTLV-I from HTLV-II infections may be important in understanding the clinical significance of retroviral coinfections.
该研究的目的是确定人类免疫缺陷病毒（HIV）-1感染门诊患者中人类嗜T淋巴细胞病毒I型和II型（HTLV-I和HTLV-II）感染的血清流行率，并确定与HTLV-I/II感染相关的人口统计学、临床特征及实验室检查结果。1993年至1995年期间，854例患者在进入门诊时接受了HTLV-I/II感染检测，其中25例感染HTLV-I，35例感染HTLV-II。多变量分析显示，合并感染的患者更可能为黑人、年龄超过35岁且有注射吸毒史。与仅感染HIV的患者相比，HIV-1/HTLV-I合并感染患者入院时CD8计数中位数较高（p<0.05），HIV-1/HTLV-II合并感染患者CD4计数百分比中位数较高（p<0.05）。合并感染与艾滋病诊断增加无关。这些发现表明，HIV-1/HTLV-I/II合并感染经常被诊断出来，并且与独特的免疫表型相关。鉴于缺乏关于双重感染对临床状态影响的信息，区分HTLV-I和HTLV-II感染对于理解逆转录病毒合并感染的临床意义可能很重要。
