Setoyama M, Kanda A, Kanzaki T
Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.
Am J Dermatopathol. 1996 Dec;18(6):629-32. doi: 10.1097/00000372-199612000-00015.
Sarcomas seldom metastasize to the skin. This report describes a rare instance of this phenomenon. A 24-year-old patient with a history of osteosarcoma (osteoblastic type) of the right humerus was seen with a cutaneous nodule on the left temple. Histologic examination of the skin showed the lesion to be a metastatic osteosarcoma. On histologic examination, a proliferation of bizarre mononucleated or multinucleated osteoblastic cells was noted in the dermis and subcutis. Although osteoid formation and calcification were not recognized, as they had been in contrast to the primary lesion, basic structures and components of the skin lesion were identical to those of the primary tumor tissue. Cutaneous metastasis from on osteosarcoma of bone is an extraordinarily rare event and, as far as we can determine, has only been reported three times.
肉瘤很少转移至皮肤。本报告描述了这一现象的罕见病例。一名24岁有右肱骨骨肉瘤（成骨细胞型）病史的患者，左侧颞部出现一个皮肤结节。皮肤组织学检查显示该病变为转移性骨肉瘤。组织学检查发现，真皮和皮下组织中有奇异的单核或多核成骨细胞增殖。尽管未发现类骨质形成和钙化，而在原发病变中可见此类现象，但皮肤病变的基本结构和成分与原发肿瘤组织相同。骨骨肉瘤发生皮肤转移极为罕见，据我们所知，仅有三次相关报道。
