Lancaster K J, Liang C Y, Myers J C, McCabe K M
Department of Pathology, Wilford Hall Medical Center/PSLC, Lackland Air Force Base, TX 78236-5300, U.S.A.
Am J Surg Pathol. 1997 Jan;21(1):109-13. doi: 10.1097/00000478-199701000-00012.
Goblet cell carcinoid (GCC) is a rare but distinctive neoplasm with features of both adenocarcinoma and carcinoid tumor. Most cases described in the literature have occurred in the appendix. An additional well-defined location is the ovary, and these tumors have been associated with a mature teratoma of the ovary. GCC arising within a mature teratoma of the mediastinum has not been described in the English-language literature. We report a case of this previously undescribed entity and provide a review of the literature on mediastinal teratomas with malignant transformation. The histologic findings included uniform, smooth-bordered glandular nests lined by goblet cells and admixed endocrine and Paneth cells. Occasional tubular glands were present, as were transitional type glands with both goblet cell and tubular features. Cytologic atypia was minimal, and mitotic activity was rare. Immunohistochemical studies showed positive staining of GCC tumor cells with chromogranin, cytokeratin, neuron-specific enolase, serotonin (focal), and Leu-7 (focal). The GCC component was entirely contained within the mature teratoma.
杯状细胞类癌（GCC）是一种罕见但独特的肿瘤，兼具腺癌和类癌肿瘤的特征。文献中描述的大多数病例发生在阑尾。另一个明确的发病部位是卵巢，这些肿瘤与卵巢成熟畸胎瘤有关。纵隔成熟畸胎瘤内发生的GCC在英文文献中尚未见报道。我们报告一例此前未描述过的此类病例，并对纵隔畸胎瘤恶变的文献进行综述。组织学表现包括由杯状细胞衬覆的均匀、边界光滑的腺巢，混有内分泌细胞和潘氏细胞。偶见管状腺，也有兼具杯状细胞和管状特征的移行型腺。细胞异型性极小，有丝分裂活性罕见。免疫组化研究显示GCC肿瘤细胞嗜铬粒蛋白、细胞角蛋白、神经元特异性烯醇化酶、血清素（局灶性）和Leu-7（局灶性）染色阳性。GCC成分完全包含在成熟畸胎瘤内。
