Standley C A, Whitty J E, Mason B A, Cotton D B
Department of Obstetrics and Gynecology, Wayne State University School of Medicine/Detroit Medical Center, Michigan, USA.
Obstet Gynecol. 1997 Jan;89(1):24-7. doi: 10.1016/s0029-7844(96)00380-8.
To compare serum levels of ionized and total magnesium with those of ionized calcium, total calcium, sodium, and potassium over the course of pregnancy in normal women and in women who develop preeclampsia.
We collected venous serum samples from 31 pregnant women during their first, second, and third trimesters. Gestational ages ranged from 6 to 37 weeks. Samples were analyzed for ionized and total magnesium, ionized and total calcium, sodium, and potassium using a biomedical chemistry analyzer. Data were analyzed with repeated-measures analysis of variance and two-way repeated-measured analysis of variance.
In 22 normal pregnant women, both serum ionized and total magnesium levels decreased significantly with increasing gestational age. No changes in sodium, potassium, or ionized or total calcium were observed. Nine of the 31 subjects developed preeclampsia by term; serum total magnesium levels decreased significantly by the second trimester in these women compared with those of normal pregnant women.
Our results provide evidence of decreases in ionized and total magnesium levels with increasing gestational age during normal pregnancy, as well as evidence of a magnesium disturbance in women who later develop preeclampsia. Future studies of magnesium balance in women at risk for developing complications of pregnancy are indicated.
比较正常孕妇和发生子痫前期孕妇在孕期过程中血清离子镁和总镁水平与离子钙、总钙、钠和钾水平。
我们收集了31名孕妇在孕早期、孕中期和孕晚期的静脉血清样本。孕周范围为6至37周。使用生物医学化学分析仪对样本进行离子镁和总镁、离子钙和总钙、钠和钾的分析。数据采用重复测量方差分析和双向重复测量方差分析。
在22名正常孕妇中，血清离子镁和总镁水平均随孕周增加而显著降低。钠、钾、离子钙或总钙未见变化。31名受试者中有9名在足月时发生子痫前期；与正常孕妇相比，这些女性在孕中期血清总镁水平显著降低。
我们的结果提供了正常孕期离子镁和总镁水平随孕周增加而降低的证据，以及后期发生子痫前期女性存在镁紊乱的证据。提示未来需对有妊娠并发症风险女性的镁平衡进行研究。
