Russell M B, Andersson P G, Iselius L
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Headache. 1996 Nov-Dec;36(10):608-12. doi: 10.1046/j.1526-4610.1996.3610608.x.
We investigated the familial occurrence of cluster headache in 370 probands with cluster headache, diagnosed according to the operational diagnostic criteria of the international Headache Society. Seven probands belonged to three families. A positive family history of cluster headache was found in 7% (25 of 366) of the families. Compared with the general population, the first- and second-degree relatives of the 370 probands with cluster headache had a 14- and 2-fold increased risk of having cluster headache, after standardization for sex and age. This increased familial risk strongly suggests that cluster headache has a genetic cause. The patterns of segregation were assessed by complex segregation analysis performed with the computer program, POINTER. The segregation analysis suggests that cluster headache has an autosomal dominant gene with a penetrance of 0.30 to 0.34 in males and 0.17 to 0.21 in females. The gene is present in 3% to 4% of males and 7% to 10% of females with cluster headache.
我们依据国际头痛协会的操作性诊断标准，对370例丛集性头痛先证者的丛集性头痛家族发病情况进行了调查。7例先证者分属于3个家族。在7%（366个家族中的25个）的家族中发现了丛集性头痛的阳性家族史。与普通人群相比，370例丛集性头痛先证者的一级和二级亲属在经过性别和年龄标准化后，患丛集性头痛的风险分别增加了14倍和2倍。这种家族风险的增加强烈提示丛集性头痛有遗传病因。通过使用计算机程序POINTER进行复杂分离分析来评估分离模式。分离分析表明，丛集性头痛有一个常染色体显性基因，在男性中的外显率为0.30至0.34，在女性中的外显率为0.17至0.21。该基因在3%至4%的丛集性头痛男性患者和7%至10%的丛集性头痛女性患者中存在。
