Russell M B, Andersson P G, Thomsen L L, Iselius L
Department of Neurology, University of Copenhagen, Denmark.
J Med Genet. 1995 Dec;32(12):954-6. doi: 10.1136/jmg.32.12.954.
We investigated the mode of inheritance of cluster headache in 370 families. The probands were from a neurological clinic in Jutland and two departments of neurology in Copenhagen County, Denmark. The criteria of the International Headache Society were used. The patterns of segregation of cluster headache were assessed by complex segregation analysis performed with the computer program POINTER. Of the 370 probands with cluster headache, 25 had 36 relatives with cluster headache. The segregation analysis suggests that cluster headache has an autosomal dominant gene (p < 0.10) with a penetrance of 0.30-0.34 in males and 0.17-0.21 in females. The gene is present in 3 to 4% of males and 7 to 10% of females with cluster headache. An autosomal dominant gene has a role in cluster headache in some families.
我们研究了370个家庭中丛集性头痛的遗传模式。先证者来自日德兰半岛的一家神经科诊所和丹麦哥本哈根郡的两个神经科。采用了国际头痛协会的标准。通过使用计算机程序POINTER进行的复杂分离分析来评估丛集性头痛的分离模式。在370例丛集性头痛先证者中，有25例有36名患有丛集性头痛的亲属。分离分析表明，丛集性头痛有一个常染色体显性基因（p < 0.10），在男性中的外显率为0.30 - 0.34，在女性中为0.17 - 0.21。该基因在患有丛集性头痛的男性中占3%至4%，在女性中占7%至10%。常染色体显性基因在一些家庭的丛集性头痛中起作用。
