Tréfouret S, Azulay J P, Pouget J, Boucraut J, Serratrice G
Service de Neurologie et Maladies Neuromusculaires, CHU La Timone, Marseille.
Rev Neurol (Paris). 1996 Aug-Sep;152(8-9):554-6.
Four patients older than 45 years with a central nervous system demyelinating disease associated to a monoclonal gammopathy are reported. The neurologic disease met the diagnostic criteria of multiple sclerosis, with the particularity of a late onset. Monoclonal paraproteinemia was also present in the cerebrospinal fluid, associated with an intrathecal immunoglobulin synthesis. The clinical data and the course of the disease were comparable to the previous reports of late onset multiple sclerosis. A causal link between the dysglobulinemia and the neurological disease may not be demonstrated. However, such an association may underline the role of humoral processes in multiple sclerosis.
本文报告了4例年龄大于45岁、患有与单克隆丙种球蛋白病相关的中枢神经系统脱髓鞘疾病的患者。该神经系统疾病符合多发性硬化症的诊断标准，其特点是发病较晚。脑脊液中也存在单克隆副蛋白血症，并伴有鞘内免疫球蛋白合成。临床资料和疾病进程与既往迟发性多发性硬化症的报道相似。球蛋白异常血症与神经系统疾病之间的因果关系尚未得到证实。然而，这种关联可能凸显了体液免疫过程在多发性硬化症中的作用。
