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失落的和弦：微嵌合体与同种异体移植存活

The lost chord: microchimerism and allograft survival.

作者信息

Starzl T E, Demetris A J, Murase N, Trucco M, Thomson A W, Rao A S

机构信息

Pittsburgh Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA.

出版信息

Immunol Today. 1996 Dec;17(12):577-84; discussion 588. doi: 10.1016/s0167-5699(96)10070-0.

DOI:10.1016/s0167-5699(96)10070-0
PMID:8991290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2993493/
Abstract

Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allografts. Here, Thomas Starzl and colleagues argure that this hematolymphopoietic chimerism provides an important framework for the interpretation of basic and therapeutically oriented transplantataion research.

摘要

最近的证据表明，过客白细胞在器官移植后迁移并产生持续的嵌合现象，这对于同种异体移植物的持续存活至关重要。在此，托马斯·斯塔兹尔及其同事认为，这种血液淋巴造血嵌合现象为解释基础和治疗导向的移植研究提供了一个重要框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/bc8f4565da04/nihms249157f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/17097672f11a/nihms249157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/bafaa228c016/nihms249157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/e9633c8b7da5/nihms249157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/2b3f34cce6bd/nihms249157f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/bc8f4565da04/nihms249157f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/17097672f11a/nihms249157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/bafaa228c016/nihms249157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/e9633c8b7da5/nihms249157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/2b3f34cce6bd/nihms249157f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db2a/2993493/bc8f4565da04/nihms249157f5.jpg

相似文献

1
The lost chord: microchimerism and allograft survival.失落的和弦：微嵌合体与同种异体移植存活
Immunol Today. 1996 Dec;17(12):577-84; discussion 588. doi: 10.1016/s0167-5699(96)10070-0.
2
Microchimerism and heart allograft acceptance.微嵌合体与心脏同种异体移植的接受
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4
Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients.有证据表明，对于接受抗CD4治疗的受者，体内维持对同种异体抗原的耐受性而言，器官移植物的持续存在而非外周供体微嵌合体是至关重要的。
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Donor microchimerism is not responsible for the maintenance of tolerance to donor alloantigens in recipients tolerant of cardiac allografts.供体微嵌合体并非维持心脏同种异体移植受者对供体同种异体抗原耐受性的原因。
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Microchimerism in a human hand allograft.
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引用本文的文献

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Transpl Int. 2024 Oct 30;37:12822. doi: 10.3389/ti.2024.12822. eCollection 2024.
2
The applications of bone marrow-derived stem cells to induce tolerance and chimerism in organ transplantation.骨髓源性干细胞在器官移植中诱导免疫耐受和嵌合体形成的应用。
Int J Organ Transplant Med. 2010;1(4):157-69.
3
Historical overview of transplantation.移植的历史概述。

本文引用的文献

1
The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council.兔自体皮肤移植和同种异体皮肤移植的行为与转归：提交给医学研究委员会战争创伤委员会的报告
J Anat. 1944 Oct;78(Pt 5):176-99.
2
FACTORS DETERMINING SHORT- AND LONG-TERM SURVIVAL AFTER ORTHOTOPIC LIVER HOMOTRANSPLANTATION IN THE DOG.犬原位肝同种移植术后短期和长期存活的决定因素
Surgery. 1965 Jul;58:131-55.
3
THE REVERSAL OF REJECTION IN HUMAN RENAL HOMOGRAFTS WITH SUBSEQUENT DEVELOPMENT OF HOMOGRAFT TOLERANCE.
Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a014977. doi: 10.1101/cshperspect.a014977.
4
Composite tissue allotransplantation immunology.复合组织同种异体移植免疫学
Arch Plast Surg. 2013 Mar;40(2):141-53. doi: 10.5999/aps.2013.40.2.141. Epub 2013 Mar 11.
5
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.Flt3L 联合雷帕霉素通过诱导调节性树突状细胞和同种异体移植自噬促进小鼠心脏移植物耐受。
PLoS One. 2012;7(10):e46230. doi: 10.1371/journal.pone.0046230. Epub 2012 Oct 2.
6
The basis of allograft acceptance.同种异体移植接受的基础。
Forum (Genova). 1997;7(Suppl 6):7-18.
7
On the crossroad between tolerance and posttransplant lymphoma.在耐受性与移植后淋巴瘤的十字路口。
Curr Opin Organ Transplant. 1997 Oct 1;2(1):30-35. doi: 10.1097/00075200-199710000-00007.
8
Special regulatory T-cell review: Regulation of immune responses--examining the role of T cells.特殊调节性T细胞综述：免疫反应的调节——审视T细胞的作用。
Immunology. 2008 Jan;123(1):13-6. doi: 10.1111/j.1365-2567.2007.02775.x.
9
Acquired immunologic tolerance: with particular reference to transplantation.获得性免疫耐受：特别是关于移植方面
Immunol Res. 2007;38(1-3):6-41. doi: 10.1007/s12026-007-0001-7.
10
Effect of operation-synchronizing transfusion of apoptotic spleen cells from donor rats on acute rejection of recipient rats after liver transplantation.供体大鼠凋亡脾细胞手术同步输注对肝移植受体大鼠急性排斥反应的影响
World J Gastroenterol. 2005 Feb 28;11(8):1161-6. doi: 10.3748/wjg.v11.i8.1161.
人类肾移植排斥反应的逆转及随后同种移植耐受性的发展
Surg Gynecol Obstet. 1963 Oct;117:385-95.
4
Graft versus host reactions. Their natural history, and applicability as tools of research.移植物抗宿主反应。其自然史及其作为研究工具的适用性。
Prog Allergy. 1962;6:349-467.
5
The homograft reaction.同种移植反应。
Annu Rev Microbiol. 1957;11:439-58. doi: 10.1146/annurev.mi.11.100157.002255.
6
The impact on the developing embryo and newborn animal of adult homologous cells.成年同源细胞对发育中胚胎和新生动物的影响。
Acta Pathol Microbiol Scand. 1957;40(6):480-500.
7
A simple method for inducing tolerance of skin homografts in mice.一种诱导小鼠皮肤同种异体移植耐受的简单方法。
Transplant Bull. 1957 Apr;4(2):67-71.
8
Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow.高剂量X射线照射及给予同源骨髓后成功的皮肤同种移植。
J Natl Cancer Inst. 1955 Feb;15(4):1023-9.
9
Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
10
Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes.
Transpl Int. 1996;9(6):593-5. doi: 10.1007/BF00335561.