整合素作为杂乱的信号转导装置。
Integrins as promiscuous signal transduction devices.
作者信息
Petty H R, Todd R F
机构信息
Dept of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
出版信息
Immunol Today. 1996 May;17(5):209-12. doi: 10.1016/0167-5699(96)30013-3.
PMID:8991380
Abstract
Recent studies suggest physical and functional interactions of glycosylphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) with leukocyte beta 2 integrins. As discussed in this article, it now appears that beta 2 integrins relay proinflammatory information from GPI-anchored membrane receptors to the cytoplasm via exodomain interactions.
摘要
最近的研究表明，糖基磷脂酰肌醇（GPI）连接蛋白（CD14、CD16b和CD87）与白细胞β2整合素之间存在物理和功能相互作用。如本文所讨论的，现在看来，β2整合素通过胞外域相互作用将来自GPI锚定膜受体的促炎信息传递到细胞质中。
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