白细胞介素-4诱导的免疫偏离作为炎症性自身免疫病的抗原特异性疗法。
IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.
作者信息
Röcken M, Racke M, Shevach E M
机构信息
Dept of Dermatology, Ludwig-Maximilians-University Munich, Germany.
出版信息
Immunol Today. 1996 May;17(5):225-31. doi: 10.1016/0167-5699(96)80556-1.
PMID:8991384
Abstract
Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Röcken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.
摘要
器官特异性自身免疫性疾病由产生干扰素γ（IFN-γ）的辅助性T细胞1（Th1）介导。在此，马丁·勒肯及其同事综述了针对炎性自身免疫性疾病的抗原特异性治疗方法的实验依据。该策略涉及将有害的Th1反应选择性地偏向产生抗炎性白细胞介素4（IL-4）的Th2表型。
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