Agadzhanian N A, Torshin V I
Aviakosm Ekolog Med. 1996;30(4):40-4.
The article reviews the factors of abiotic and biotic environments liable to provoke convulsions. An assumption is made that the common element of their action on the organism are hypoxic states of varying types and depth. Animals with high individual tolerance of acute hypoxia were found to possess a better resistance to the convulsing effect of penicillin. In these animals the epilepsy-form discharges appear with longer latent periods and the epilepsy-form seizures are generated much more seldom in contrast to rats with poor tolerance of hypoxia. Training of resistless rats in the altitude chamber increases their ability to oppose the convulsing effect of penicillin to the level of animals with moderate but not high hypoxia tolerance.
本文综述了可能引发惊厥的非生物和生物环境因素。假设它们对机体作用的共同要素是不同类型和深度的缺氧状态。发现对急性缺氧具有高个体耐受性的动物对青霉素的惊厥作用具有更好的抵抗力。与缺氧耐受性差的大鼠相比，这些动物的癫痫样放电潜伏期更长，癫痫样发作也很少发生。在高原舱中对耐受性差的大鼠进行训练，可将它们对抗青霉素惊厥作用的能力提高到具有中等但非高缺氧耐受性动物的水平。
