Urbanová D, Pelouch V, Ostádal B, Widimský J, Ressl J, Procházka J
Cor Vasa. 1977;19(3):246-50.
The initial phase and the development of myocardial focal necroses were studied in 50 rats adapted successively to intermittent high altitude. The altitude hypoxia was produced in a low pressure chamber (7000 m, five days a week, four hours daily). First-minute myocardial changes detected by histochemical methods were found after 4 exposures at a level of 3000 m and distinct ones after 8 exposures at a level of 4500 m. Histologically, acute focal necroses were found after 11 exposures at a level of 6000 m. Hypoxia and stress are suggested to account for these myocardial focal changes. During further adaptation no further acute focal necroses were observed.
对50只先后适应间歇性高海拔环境的大鼠进行了心肌局灶性坏死的初始阶段和发展情况的研究。在低压舱（7000米，每周五天，每天四小时）中制造海拔缺氧环境。通过组织化学方法检测到的第一分钟心肌变化在海拔3000米暴露4次后出现，在海拔4500米暴露8次后出现明显变化。组织学上，在海拔6000米暴露11次后发现急性局灶性坏死。提示缺氧和应激是这些心肌局灶性变化的原因。在进一步适应过程中未观察到进一步的急性局灶性坏死。
