Re M C, Furlini G, Vignoli M, Ramazzotti E, Zauli G, La Placa M
Institute of Microbiology, University of Bologna, St. Orsola General Hospital, Italy.
Clin Diagn Lab Immunol. 1996 Mar;3(2):230-2. doi: 10.1128/cdli.3.2.230-232.1996.
Retrospective analysis of serum samples from a group of hemophiliac patients who became infected with human immunodeficiency virus type 1 (HIV-1) between 1984 and 1985 has shown that, at variance with other HIV-1-infected patients, at the onset, or at least at a very early phase of HIV-1 infection, they constantly have elevated levels of antibodies against HIV-1-transactivating Tat protein and an absent or barely detectable p24 antigenemia. Anti-Tat antibodies in initial serum samples from hemophiliac patients were probably the consequence of the passive administration of immunoglobulins present in low- or intermediate-purity clotting factor concentrates prepared from HIV-1-infected blood. Furthermore, the analysis of serial serum samples obtained during the course of the disease, in which passively acquired anti-Tat antibodies were substituted by actively produced antibodies, demonstrated an inverse relationship between anti-Tat antibody and p24 anti-genemia levels throughout the observation period. These data seem to suggest that anti-Tat antibody may have some influence on the course of HIV-1 infection.
对一组在1984年至1985年间感染了1型人类免疫缺陷病毒（HIV-1）的血友病患者的血清样本进行回顾性分析表明，与其他感染HIV-1的患者不同，在HIV-1感染开始时，或至少在感染的极早期阶段，他们体内抗HIV-1反式激活蛋白Tat的抗体水平持续升高，且p24抗原血症缺失或几乎检测不到。血友病患者初始血清样本中的抗Tat抗体可能是由于被动输入了由感染HIV-1的血液制备的低纯度或中等纯度凝血因子浓缩物中所含的免疫球蛋白。此外，对疾病过程中获取的系列血清样本进行分析，其中被动获得的抗Tat抗体被主动产生的抗体所取代，结果表明在整个观察期内，抗Tat抗体与p24抗原血症水平呈负相关。这些数据似乎表明抗Tat抗体可能对HIV-1感染的病程有一定影响。
