Juanola X, Mateo L, Domenech P, Bas J, Contreras N, Nolla J M, Roig-Escofet D
Department of Rheumatology, Hematology, and Immunology, L'Hospitalet de Llobregat, Barcelona, Spain.
J Rheumatol. 1995 Oct;22(10):1891-3.
To establish the prevalence of antiphospholipid antibodies (aPL) in a group of patients with ankylosing spondylitis (AS). The relation of the antibodies with different clinical and analytical features was studied.
Eighty-four patients with AS (71 men) and 40 age and sex matched controls were studied. aPL determinations included: anticardiolipin antibodies (aCL) of the IgM, IgG, and IgA classes, the presence of lupus anticoagulant (LAC), and a false positive serologic test for syphilis. Comparisons between variables were done by Student t test, Mann-Whitney test and Chi squared test. Correlations between aPL and clinical variables were performed by Pearson coefficients.
Twenty-four patients with AS (29%) has positive IgG aCL, compared with only 2 cases in the control group (5%) (p < 0.002). There were no differences in other aPL determinations between patients and controls. There was no correlation between the presence of aCL (IgG, IgM, or IgA) and LAC and the different aspects of the disease. Two patients fulfilled the criteria for antiphospholipid syndrome.
Our results indicate the presence of IgG aCL in patients with AS higher than in the normal population but their relation with thrombosis and other systemic manifestations seems weak.
确定一组强直性脊柱炎（AS）患者中抗磷脂抗体（aPL）的患病率。研究这些抗体与不同临床和分析特征之间的关系。
对84例AS患者（71例男性）和40例年龄及性别匹配的对照者进行研究。aPL检测包括：IgM、IgG和IgA类抗心磷脂抗体（aCL）、狼疮抗凝物（LAC）的存在情况以及梅毒血清学假阳性试验。变量之间的比较采用Student t检验、Mann-Whitney检验和卡方检验。aPL与临床变量之间的相关性通过Pearson系数进行分析。
24例AS患者（29%）IgG aCL呈阳性，而对照组仅2例（5%）呈阳性（p < 0.002）。患者和对照组在其他aPL检测方面无差异。aCL（IgG、IgM或IgA）和LAC的存在与疾病的不同方面之间无相关性。2例患者符合抗磷脂综合征的标准。
我们的结果表明，AS患者中IgG aCL的存在高于正常人群，但它们与血栓形成及其他全身表现之间的关系似乎较弱。
