Zilov V G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1977 May-Jun;27(3):521-9.
Neurophysiological and neurochemical mechanisms of inhibitory influences of the frontal cortex on feeding both natural and evoked by electrical stimulation of the lateral hypothalamus were studied in experiments on rabbits. It was shown that frontal cortical inhibition of feeding was eliminated by ipsilateral coagulation of the dorsal hippocampus. Different effects of some drugs on the threshold of evoked feeding and on the cortical inhibition were observed. Atropine (1 mg/kg) and Droperidol (0,3 mg/kg) abolished the inhibitory influences of the frontal cortex. Chlorpromazine (2 mg/kg) increased the threshold of feeding elicited by the stimulation of the hypothalamic "feeding centre" and had no effect on frontal cortical inhibition. Different influences of chlorpromazine on natural and evoked feeding were shown. A conclusion is drawn about different transmitters in brain structures involved in functional architectonics of feeding. Mechanisms of drugs' action on feeding are discussed.
在对家兔的实验中，研究了额叶皮层对自然进食以及下丘脑外侧电刺激诱发进食的抑制作用的神经生理和神经化学机制。结果表明，通过同侧凝固背侧海马可消除额叶皮层对进食的抑制作用。观察到一些药物对诱发进食阈值和皮层抑制有不同影响。阿托品（1毫克/千克）和氟哌利多（0.3毫克/千克）消除了额叶皮层的抑制作用。氯丙嗪（2毫克/千克）提高了下丘脑“进食中枢”刺激诱发进食的阈值，对额叶皮层抑制无影响。显示了氯丙嗪对自然进食和诱发进食的不同影响。得出了关于参与进食功能结构的脑结构中不同递质的结论。讨论了药物对进食作用的机制。
