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[对P物质诱导的由下丘脑外侧电刺激引起的摄食行为重新排序的神经化学分析]

[A neurochemical analysis of the substance P-induced reordering of the feeding behavior evoked by electrical stimulation of the lateral hypothalamus].

作者信息

Zilov V G, Patyshakuliev A P, Rogacheva S K, Ivanova L I

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 Mar-Apr;43(2):351-7.

PMID:7686318
Abstract

The substance P when administered intracerebroventricularly (15 nmol) led to a transformation of feeding elicited by threshold electrical stimulation of the lateral hypothalamus into an escape reaction in rabbits. Obsidan, Inderal (0.25 and 0.5 mg) and droperidol (0.3 mg) injected intravenously were found to restore the functional properties of the hypothalamic feeding centre. No changes in the escape reaction were observed after kalipsol (ketaminum) administration. The data obtained suggest the important role of the catecholaminergic brain structures in the mechanisms of the transformation of the functional properties of the hypothalamic feeding centre under the influence of the substance P.

摘要

脑室内注射P物质（15纳摩尔）可使家兔下丘脑外侧受到阈强度电刺激时引起的摄食行为转变为逃避反应。静脉注射心得安（0.25毫克和0.5毫克）、心得宁及氟哌啶醇（0.3毫克）可使下丘脑摄食中枢的功能特性恢复正常。注射氯胺酮后未观察到逃避反应有变化。所获数据提示，儿茶酚胺能脑结构在P物质影响下下丘脑摄食中枢功能特性转变机制中起重要作用。

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