Zilov V G, Rogacheva S K
Biull Eksp Biol Med. 1976 Mar;81(3):267-9.
The influences of droperidol (butyrophenon derivative) on feeding reaction evoked by electrical stimulation of the hypothalamic "feeding centre" were investigated in unrestricted rabbits. Intravenous injection of droperidol (0.3 mg/kg) decreased the threshold of evoked feeding. Inhibitory influences of the anterior areas of the brain cortex on feeding reactions were absent in the animals under droperidol, but the facilitating influences of the posterior areas of the brain cortex on feeding reactions were retained or even became stronger. These findings are explained by dophamine-negative action of droperidol and by disturbances of the inhibitory system of the brain.
在自由活动的家兔身上，研究了氟哌利多（丁酰苯衍生物）对电刺激下丘脑“摄食中枢”所诱发的摄食反应的影响。静脉注射氟哌利多（0.3毫克/千克）降低了诱发摄食的阈值。在使用氟哌利多的动物中，大脑皮层前部区域对摄食反应的抑制作用消失，但大脑皮层后部区域对摄食反应的促进作用得以保留甚至增强。这些发现可以用氟哌利多的多巴胺拮抗作用以及大脑抑制系统的紊乱来解释。
