Stohler R, Hug I, Knoll B, Mohler B, Ladewig D
Psychiatrische Universitätsklinik, Basel.
Praxis (Bern 1994). 1996 Nov 26;85(48):1537-41.
Since the beginning of the 'Janus' opiate project in Basel in which severely opiate-dependent persons are treated intravenously with heroin, morphine or methadone 11 from 160 participants (to november 1995) were treated in the withdrawal and intervention unit at the psychiatry clinic of the university of Basel. 7 patients sought a total, 4 a partial withdrawal. Whereas the 4 patients wanting withdrawal from consumption of drugs in addition to study drugs all reached their goal 4 of the 7 persons aiming at total withdrawal interrupted treatment prematurely. The 3 patients who were successful are-as far as the authors know-still off opiates. Substitution of intravenous opiates provided by 'Janus' with oral methadone and slow tapering off of the latter over days to weeks occurred mostly without problems. Participants of the 'Janus' project thus desired a withdrawal oriented treatment with equal frequency and had not less success than persons substituted with oral methadone in achieving this goal.
自巴塞尔开展“杰纳斯”阿片类药物项目以来，该项目对严重阿片类药物依赖者采用海洛因、吗啡或美沙酮进行静脉治疗。截至1995年11月，巴塞尔大学精神病学诊所的戒断与干预病房共治疗了160名参与者中的11人。7名患者寻求完全戒断，4名患者寻求部分戒断。除研究药物外，4名希望停止使用毒品的患者均实现了目标，而7名旨在完全戒断的患者中有4名过早中断了治疗。据作者所知，成功的3名患者至今仍未使用阿片类药物。用口服美沙酮替代“杰纳斯”项目提供的静脉注射阿片类药物，并在数天至数周内逐渐减少美沙酮用量，大多情况下没有问题。“杰纳斯”项目的参与者同样频繁地希望接受以戒断为导向的治疗，并且在实现这一目标方面取得的成功并不亚于接受口服美沙酮替代治疗的人。
