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[人类天花免疫方法与手段的比较评估]

[Comparative assessment of the means and methods of immunizing humans against smallpox].

作者信息

Agafonov V I, Vorob'ev A A, Gapochko K G, Marennikova S S, Patrikeev G T

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1977 Jun(6):31-5.

PMID:899432
Abstract

Serological efficacy of oral smallpox vaccination was studied in comparison with the scarification and jet methods (1677 persons were vaccinated orally, 148 by scarification, and 1864 by the jet method). In all the three groups percentage of persons with increase of antibodies in comparison with the initial level proved to be statistically equal, constituting about 80% the first 5 months, and falling to 39-61% in 12 months. After revaccination by the scarification and jet methods the mean geometrical antibody titres increased 11--14-fold, and after oral revaccination--5-fold. However, not in a single case they were below 1:25 (observation time--up to 5 months). Vaccination teams consisting of 2--3 persons were capable of vaccinating by the oral method 1456 persons, by the jet method 891 persons, and by scarfication 27 persons per hour.

摘要

对口服天花疫苗的血清学效果进行了研究,并与划痕法和喷射法进行了比较(1677人采用口服法接种,148人采用划痕法接种,1864人采用喷射法接种)。在所有三组中,与初始水平相比抗体增加的人员百分比经统计学检验是相等的,在前5个月约为80%,12个月时降至39% - 61%。采用划痕法和喷射法再次接种后,平均几何抗体滴度增加了11 - 14倍,口服再次接种后增加了5倍。然而,在任何情况下其均不低于1:25(观察时间长达5个月)。由2 - 3人组成的接种团队每小时能够采用口服法为1456人接种,采用喷射法为891人接种,采用划痕法为27人接种。

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