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人类基因组中散布重复序列的起源。

The origin of interspersed repeats in the human genome.

作者信息

Smit A F

机构信息

Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA.

出版信息

Curr Opin Genet Dev. 1996 Dec;6(6):743-8. doi: 10.1016/s0959-437x(96)80030-x.

Abstract

Over a third of the human genome consists of interspersed repetitive sequences which are primarily degenerate copies of transposable elements. In the past year, the identities of many of these transposable elements were revealed. The emerging concept is that only three mechanisms of amplification are responsible for the vast majority of interspersed repeats and that with each autonomous element a number of dependent non-autonomous sequences have co-amplified.

摘要

超过三分之一的人类基因组由散布的重复序列组成,这些序列主要是转座元件的退化拷贝。在过去的一年里,许多此类转座元件的身份得以揭示。新出现的概念是,只有三种扩增机制负责绝大多数散布重复序列,并且随着每个自主元件的出现,一些依赖的非自主序列也共同扩增。

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