人癌胚抗原和胆汁糖蛋白可作为小鼠肝炎病毒的受体。
Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors.
作者信息
Chen D S, Asanaka M, Chen F S, Shively J E, Lai M M
机构信息
Howard Hughes Medical Institute, University of Southern California School of Medicine, Los Angeles 90033-1054, USA.
出版信息
J Virol. 1997 Feb;71(2):1688-91. doi: 10.1128/JVI.71.2.1688-1691.1997.
Abstract
Receptors for murine coronavirus mouse hepatitis virus (MHV) are members of the murine carcinoembryonic antigen (CEA) gene family. Since MHV can also infect primates and cause central nervous system lesions (G. F. Cabirac et al., Microb. Pathog. 16:349-357, 1994; R. S. Murray et al., Virology 188:274-284, 1992), we examined whether human CEA-related molecules can be used by MHV as potential receptors. Transfection of plasmids expressing human carcinoembryonic antigen (hCEA) and human biliary glycoprotein into COS-7 cells, which lack a functional MHV receptor, conferred susceptibility to two MHV strains, A59 and MHV-2. Domain exchange experiments between human and murine CEA-related molecules identified the immunoglobulin-like loop I of hCEA as the region conferring the virus-binding specificity. This finding expands the potential MHV receptors to primate species.
摘要
鼠冠状病毒小鼠肝炎病毒（MHV）的受体是鼠癌胚抗原（CEA）基因家族的成员。由于MHV也能感染灵长类动物并引起中枢神经系统病变（G.F.卡比拉克等人，《微生物致病机制》16:349 - 357，1994；R.S.默里等人，《病毒学》188:274 - 284，1992），我们研究了人CEA相关分子是否能被MHV用作潜在受体。将表达人癌胚抗原（hCEA）和人胆汁糖蛋白的质粒转染到缺乏功能性MHV受体的COS - 7细胞中，使细胞对两种MHV毒株A59和MHV - 2敏感。人和鼠CEA相关分子之间的结构域交换实验确定hCEA的免疫球蛋白样环I是赋予病毒结合特异性的区域。这一发现将潜在的MHV受体扩展到了灵长类物种。
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本文引用的文献
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Virology. 1993 Sep;196(1):45-56. doi: 10.1006/viro.1993.1453.
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