术中近距离放射治疗对尤因肉瘤手术的影响。
The impact of intraoperative brachytherapy on surgery of Ewing's sarcoma.
作者信息
Ozaki T, Hillmann A, Rübe C, Rödl R, Hein M, Hoffmann C, Blasius S, Jürgens H, Winkelmann W
机构信息
Department of Orthopaedics, Westfälische Wilhelms-University, Münster, Germany.
出版信息
J Cancer Res Clin Oncol. 1997;123(1):53-6. doi: 10.1007/BF01212615.
Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a series of 42 patients receiving surgery without brachytherapy. The dose of intraoperative brachytherapy ranged between 9 Gy and 21 Gy. The average operation time was longer in 20 cases with brachytherapy (7.9 h) than in 42 cases without brachytherapy (4.3 h) (P < 0.0001). The average blood loss in the groups with (3531 ml) and without brachytherapy (3515 ml) was comparable (P = 0.3840). The surgical complication rate in patients receiving brachytherapy was also similar to that of untreated patients (30% versus 31%, P = 0.7690). Local relapse developed in 1 of 20 patients who received brachytherapy and 1 of 42 patients without brachytherapy. On the basis of this analysis, it can be concluded that this procedure is safe and does not increase of the acute complication rate. The latest results of local controls are awaited.
尤因肉瘤手术有时会导致手术切缘不充分。评估了术中近距离放疗对肿瘤局部控制、手术时间、失血量和手术并发症的影响，将20例接受近距离放疗的患者结果与42例未接受近距离放疗的手术患者系列结果进行比较。术中近距离放疗的剂量在9 Gy至21 Gy之间。20例接受近距离放疗的患者平均手术时间（7.9小时）比42例未接受近距离放疗的患者（4.3小时）更长（P < 0.0001）。接受和未接受近距离放疗组的平均失血量（分别为3531 ml和3515 ml）相当（P = 0.3840）。接受近距离放疗患者的手术并发症发生率也与未治疗患者相似（30%对31%，P = 0.7690）。20例接受近距离放疗的患者中有1例发生局部复发，42例未接受近距离放疗的患者中有1例发生局部复发。基于该分析，可以得出结论，该手术是安全的，且不会增加急性并发症发生率。有待观察局部控制的最新结果。
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