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在甲胎蛋白（AFP）存在的情况下培养的淋巴细胞中，对母细胞转化和免疫球蛋白释放的抑制作用。

Inhibition of blastic transformation and immunoglobulin release in lymphocytes cultured in the presence of alpha-fetoprotein (AFP).

作者信息

Czokało M, Wiśniewski L

出版信息

Exp Pathol (Jena). 1979;17(3):176-80. doi: 10.1016/s0014-4908(79)80026-5.

DOI:10.1016/s0014-4908(79)80026-5
PMID:89967
Abstract

Blastic transformation of phytohemagglutinin-stimulated lymphocytes in cultures containing various concentrations of homogenous alpha-fetoprotein (AFP) was studied. It was found that AFP in concentrations of 4-12 microgram/ml inhibits both blastic transformation and immunoglobulin release (IgA, IgG) in lymphocyte cultures. It is suggested that AFP plays an important role in immunoregulation during the fetal life.

摘要

研究了在含有不同浓度纯α-甲胎蛋白（AFP）的培养物中，植物血凝素刺激的淋巴细胞的原始细胞转化情况。结果发现，浓度为4-12微克/毫升的AFP可抑制淋巴细胞培养物中的原始细胞转化和免疫球蛋白释放（IgA、IgG）。提示AFP在胎儿期的免疫调节中起重要作用。

相似文献

1
Inhibition of blastic transformation and immunoglobulin release in lymphocytes cultured in the presence of alpha-fetoprotein (AFP).在甲胎蛋白（AFP）存在的情况下培养的淋巴细胞中，对母细胞转化和免疫球蛋白释放的抑制作用。
Exp Pathol (Jena). 1979;17(3):176-80. doi: 10.1016/s0014-4908(79)80026-5.
2
Culture conditions modify the effects exerted by human fetal alpha-fetoprotein (AFP) on some lymphocyte functions in vitro.培养条件可改变人胎儿甲胎蛋白（AFP）在体外对某些淋巴细胞功能产生的影响。
Exp Pathol. 1981;20(4):233-8. doi: 10.1016/s0232-1513(81)80028-x.
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Culture medium components modify the effects exerted by alpha-fetoprotein (AFP) on lymphocyte response.
Exp Pathol (Jena). 1980;18(5):297-301. doi: 10.1016/s0014-4908(80)80035-4.
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Inhibitory action of pig alpha-fetoprotein through early activated thymocyte surface Na+, K+-adenosinetriphosphatase.猪甲胎蛋白通过早期活化胸腺细胞表面钠钾 - 三磷酸腺苷酶的抑制作用
Folia Microbiol (Praha). 1981;26(5):417-21. doi: 10.1007/BF02927338.
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Expression of alpha-fetoprotein receptors by human T-lymphocytes during blastic transformation.人T淋巴细胞在原始转化过程中α-甲胎蛋白受体的表达
Mol Immunol. 1989 Sep;26(9):851-7. doi: 10.1016/0161-5890(89)90141-7.
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[Investigations in taeniasis patients on blood serum immunoglobulins IgG, IgA and IgM and blastic lymphocyte transformation after phytohaemagglutinin (author's transl)].
Zentralbl Bakteriol Orig A. 1977 Nov;239(3):414-8.
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Inhibition of lymphocyte proliferation by sera from patients with hepatocellular carcinoma: lack of correlation with serum alpha-fetoprotein levels.肝细胞癌患者血清对淋巴细胞增殖的抑制作用：与血清甲胎蛋白水平无关。
J Natl Cancer Inst. 1981 Apr;66(4):625-30.
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Lipid interactions with human alpha-fetoprotein (AFP). A study of the role of such interactions in the ability of human AFP to suppress lymphocyte transformation.脂质与人类甲胎蛋白（AFP）的相互作用。关于此类相互作用在人类AFP抑制淋巴细胞转化能力中所起作用的一项研究。
Oncodev Biol Med. 1980;1(4-5):273-85.
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Alpha-fetoprotein gene expression in human lymphoblastoid cells and in PHA-stimulated normal T-lymphocytes.甲胎蛋白基因在人淋巴母细胞及PHA刺激的正常T淋巴细胞中的表达
Biochem Biophys Res Commun. 1989 Feb 28;159(1):112-8. doi: 10.1016/0006-291x(89)92411-x.
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Effects of concanavalin A, phytohemagglutinin, pokeweed mitogen, and lipopolysaccharide on the replication and immunoglobulin synthesis by canine peripheral blood lymphocytes in vitro.刀豆球蛋白A、植物血凝素、商陆有丝分裂原和脂多糖对犬外周血淋巴细胞体外复制及免疫球蛋白合成的影响
Immunol Lett. 1987 Jan;14(2):79-85. doi: 10.1016/0165-2478(87)90083-6.

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