在甲胎蛋白（AFP）存在的情况下培养的淋巴细胞中，对母细胞转化和免疫球蛋白释放的抑制作用。
Inhibition of blastic transformation and immunoglobulin release in lymphocytes cultured in the presence of alpha-fetoprotein (AFP).
作者信息
Czokało M, Wiśniewski L
出版信息
Exp Pathol (Jena). 1979;17(3):176-80. doi: 10.1016/s0014-4908(79)80026-5.
PMID:89967
Abstract
Blastic transformation of phytohemagglutinin-stimulated lymphocytes in cultures containing various concentrations of homogenous alpha-fetoprotein (AFP) was studied. It was found that AFP in concentrations of 4-12 microgram/ml inhibits both blastic transformation and immunoglobulin release (IgA, IgG) in lymphocyte cultures. It is suggested that AFP plays an important role in immunoregulation during the fetal life.
摘要
研究了在含有不同浓度纯α-甲胎蛋白（AFP）的培养物中，植物血凝素刺激的淋巴细胞的原始细胞转化情况。结果发现，浓度为4-12微克/毫升的AFP可抑制淋巴细胞培养物中的原始细胞转化和免疫球蛋白释放（IgA、IgG）。提示AFP在胎儿期的免疫调节中起重要作用。
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