Karachalios G N, Nasiopoulou D D, Bourlinou P K, Reppa A
Third Department of Medicine, Red Cross Hospital, Athens, Greece.
Int J Clin Pharmacol Ther. 1996 Dec;34(12):555-7.
The combination of penicillin with an aminoglycoside has been recommended as an initial treatment of choice for patients with acute infections of the biliary tract. However, many patients have incidence of renal problems and for this reason aminoglycosides must be avoided. Newer antimicrobial agents with lesser nephrotoxic effects will be tried. We, therefore, performed a prospective, randomized trial of ofloxacin, a new quinolone and ceftriaxone in patients with acute biliary tract infections. Fifty-two patients with severe biliary tract infections (cholecystitis and cholangitis) were randomly assigned to receive either ofloxacin (n = 28) or ceftriaxone (n = 24). The 2 groups receiving antibiotics were similar with respect to all clinical and laboratory parameters. Bacteria were documented in 48% of patients in the ofloxacin group and in 46% in the ceftriaxone group. The percentage of patients with a clinical cure or significant improvement was the same in the 2 groups. No significant difference was noted between the 2 treatment groups with respect to drug toxicity. These data suggest that intravenous ofloxacin followed by oral administration is an effective and safe single drug for the therapy of patients with acute biliary tract infections.
青霉素与氨基糖苷类药物联合使用，已被推荐作为急性胆道感染患者的初始治疗选择。然而，许多患者会出现肾脏问题，因此必须避免使用氨基糖苷类药物。将尝试使用肾毒性较小的新型抗菌药物。因此，我们对急性胆道感染患者进行了一项关于氧氟沙星（一种新型喹诺酮类药物）和头孢曲松的前瞻性随机试验。52例严重胆道感染（胆囊炎和胆管炎）患者被随机分为两组，分别接受氧氟沙星治疗（n = 28）或头孢曲松治疗（n = 24）。接受抗生素治疗的两组患者在所有临床和实验室参数方面相似。氧氟沙星组48%的患者和头孢曲松组46%的患者检测到细菌。两组中临床治愈或显著改善的患者百分比相同。两组治疗在药物毒性方面无显著差异。这些数据表明，静脉注射氧氟沙星后口服给药，是治疗急性胆道感染患者的一种有效且安全的单一药物。
